Stress-Immune News

reports on new advances in the area of stress-immunity interactions

Magnified Peripheral IL-6 Response Linked To Stress Susceptibility and Higher Risk of Depression

Magnified Peripheral IL-6 Response Linked To Stress Susceptibility and Higher Risk of Depression

A new study published in the Proceedings of the National Academy of Sciences of the USA is perhaps the first to demonstrate that the magnitude of peripheral interleukin (IL)-6 responses preceding stress challenge may confer inter-individual differences in susceptibility or resilience to a subsequent social stressor. Previous research indicates that in humans both major depression […]

New Evidence That Stress In Pregnancy Increases Susceptibility to Asthma In Offspring

New Evidence That Stress In Pregnancy Increases Susceptibility to Asthma In Offspring

A recent study published in the American Journal of Physiology – Lung Cellular and Molecular Physiology indicates that release of glucocorticoids (GCs) as the result of stress during pregnancy can induce asthma susceptibility in offspring. It is known that psychological stress contributes to the pathogenesis and exacerbations of asthma. One mechanism may be the capacity […]

Large Population Study Links Stress in Middle Age Women to Dementia and Alzheimer’s Risk Decades Later

Large Population Study Links Stress in Middle Age Women to Dementia and Alzheimer’s Risk Decades Later

A Swedish study, published in the August 2013 online issue of BMJ Open indicates that a higher number of psychosocial stressors in middle-aged women were associated with increased risk of dementia and Alzheimer’s disease (AD) decades later in life. This is perhaps the first population study on the relationship between midlife stressors and increased risk […]

New Animal Stress Model Links the Stress-Induced T-helper 2 Shift to Colon Cancer Growth

New Animal Stress Model Links the Stress-Induced T-helper 2 Shift to Colon Cancer Growth

In the October 2013 issue of Biochemical and Biophysical Research Communications, Ni Hou and colleagues from the Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi, China, demonstrated that a novel form of sound stress induced a T helper (Th)2 shift and that this is related to colon cancer progression in mice. Numerous epidemiological reports indicate […]

Accumulation of Myeloid-Derived Suppressor Cells: A New Mechanism in Favor of Stress-Induced Immunosuppression?

Accumulation of Myeloid-Derived Suppressor Cells: A New Mechanism in Favor of Stress-Induced Immunosuppression?

Jianfeng Jin et al. present a mechanism for the immunosuppressive potential of chronic stress in the September 2013 issue of PLoS One. The authors focus on myeloid-derived suppressor cells (MDSCs), which have been implicated in regulation of the innate and adaptive immune responses. In tumor microenvironments, MDSC expansion is stimulated by prostaglandin E2 (PGE2) and […]

Stress and Worrying Affect Short-Term Fluctuations in Rheumatoid Arthritis Symptoms

Stress and Worrying Affect Short-Term Fluctuations in Rheumatoid Arthritis Symptoms

In the July 2013 issue of Annals of Rheumatic Diseases, Evers et al. report that stress and worrying predict indicators of rheumatoid arthritis disease activity such as fatigue and pain. Psychological stress has been linked to the onset and course of rheumatoid arthritis (RA). While for the juvenile chronic arthritis (JCA), chronic stress appear to […]

Psychological Stress May Promote Inflammation through Expansion of Immature Proinflammatory Monocytes

Psychological Stress May Promote Inflammation through Expansion of Immature Proinflammatory Monocytes

A recent study by Nicole Powell et al. published in the October 8, 2013 issue of PNAS, suggests that stress hormones may contribute to pro-inflammation through selective expansion and/or recruitment of a specific subpopulation of immature, proinflammatory monocytes. In the 1970s and 1980s stress was often considered immunosuppressive. Recent evidence, however, indicates that psychological stress […]

Corticotropin-Releasing Hormone’s Inhibition of NLRP6 Inflammasome May Trigger Stress-Induced Enteritis in Mice

Corticotropin-Releasing Hormone’s Inhibition of NLRP6 Inflammasome May Trigger Stress-Induced Enteritis in Mice

In the June 2013 issue of Gastroenterology, Sun et al. demonstrate that in mice stress is able to inhibit NLRP6, through a corticotropin-releasing hormone (CRH)-dependent mechanism and to modify the composition of the gut microbiota, leading to intestinal inflammation. It is well known that psychological stress exacerbates the symptoms of irritable bowel syndrome (IBS). Also, […]

Increased Risk of Heart Attack Linked To Polymorphism in the 5HTR2C Serotonin Receptor Gene

Increased Risk of Heart Attack Linked To Polymorphism in the 5HTR2C Serotonin Receptor Gene

In the December 2013 issue of PLOS One, a research team from the Department of Psychiatry, Duke University Medical Center, Durham, NC reports that a functional polymorphism of the 5HTR2C gene is associated with a 38% increased risk for cardiovascular disease events. This includes mortality and myocardial infarction (MI), independent of several traditional risk factors, […]

Chronic Variable Stress May Promote Autoimmunity through Induction of Glucocorticoid Resistance

Chronic Variable Stress May Promote Autoimmunity through Induction of Glucocorticoid Resistance

A new European Journal of Immunology study links chronic stress and autoimmunity through a mechanism referred to as glucocorticoid resistance. The effect of psychological stress on autoimmunity is extremely complex, at multiple levels, and can be in either direction. Often, stress is related to both induction/exacerbation and amelioration of disease activity. Stress hormones selectively suppress […]

Page 2 of 512345