News

A mix of news reporting on the latest developments in neuroendocrine-immunology & stress-immunity research

High Blood Interferon-γ Levels Linked to the Early Phase of Chronic Fatigue Syndrome

High Blood Interferon-γ Levels Linked to the Early Phase of Chronic Fatigue Syndrome

A study published in the February issue of the new journal Science Advances is perhaps the first to identify distinct stages of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Importantly, it demonstrates some immune signatures early in the course of ME/CFS that are not present in subjects with longer duration of illness. Although efforts were made to […]

Glucocorticoid Resistance of Th17 Cells in Takayasu Arteritis

Glucocorticoid Resistance of Th17 Cells in Takayasu Arteritis

A study published in the Arthritis & Rheumatology journal is perhaps the first to demonstrate that T helper (Th)1 and Th17 cells and cytokine pathways may play central role in driving systemic inflammation in Takayasu arteritis. Takayasu arteritis (TA) is a rare type of vasculitis that affects mostly middle-aged women, with greater frequency in Asia, […]

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor Agonists in a Murine Model of Rheumatoid Arthritis

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor Agonists in a Murine Model of Rheumatoid Arthritis

According to van Maanen et al., and their recent publication in PLoS One, two new experimental compounds affecting the acetylcholine-receptor system are able to delay collagen-induced arthritis (CIA) in mice, showing the therapeutic potential of chemicals targeting the α7 subunit of nicotinic acetylcholine receptors (α7nAChR). Previous research revealed that the efferent vagus nerve may decrease […]

Anxiety, Depression and Obesity May Jointly Contribute To Asthma Development

Anxiety, Depression and Obesity May Jointly Contribute To Asthma Development

A recent study by M. Brumpton et al., published in the International Journal of Epidemiology has shed light on the complex interactions and joint effects of anxiety, depression and obesity on the onset and development of asthma. Approximately 300 million people suffer from asthma, amounting to nearly 1% of the total global disease burden, worldwide. […]

Evidence that Napping May Correct Interleukin-6 Changes and the Stress Induction Caused By Sleep Deprivation

Evidence that Napping May Correct Interleukin-6 Changes and the Stress Induction Caused By Sleep Deprivation

A study published in the March issue of The Journal of Clinical Endocrinology & Metabolism (JCEM) indicates that short-term napping is able to restore, to a great extent, the neurohormonal and immune changes induced by sleep deprivation. Insufficient sleep is well-known to be associated with poor attention and performance deficits. However, an increasing body of […]

Blood Levels of the New Anti-Inflammatory Cytokine IL-37 Are Increased In Rheumatoid Arthritis Patients

Blood Levels of the New Anti-Inflammatory Cytokine IL-37 Are Increased In Rheumatoid Arthritis Patients

A recent study published in PLoS One suggests that interleukin (IL)-17 is involved in a control circuit that tries to regulate inflammation in rheumatoid arthritis. Rheumatoid arthritis (RA) is associated with increased levels of pro-inflammatory cytokines such as IL-6, IL-17A and tumor necrosis factor (TNF)-α. Early intervention and treatment of RA is based on disease-modifying […]

TRPV1 Sensory Nerves May Be Key to the Genesis of Airway Hyperreactivity in Experimental Asthma

TRPV1 Sensory Nerves May Be Key to the Genesis of Airway Hyperreactivity in Experimental Asthma

A new study in the Proceedings of the National Academy of Sciences (PNAS) of the USA implicates the transient receptor potential vanilloid 1 (TRPV1)-expressing sensory nerves in the pathogenesis of asthma and/or asthma attacks. The TRPV1 receptor, initially identified as the receptor for capsaicin, the hot component of chilli peppers, is typically expressed in sensory […]

Blocking IL-12 and IL-23 in APPPS1 Mouse Model Shows Promise as an Experimental Therapeutic Approach to Alzheimer’s Disease

Blocking IL-12 and IL-23 in APPPS1 Mouse Model Shows Promise as an Experimental Therapeutic Approach to Alzheimer’s Disease

A recent study, published in Nature Medicine is perhaps the first one to show interleukin (IL)-23 involvement, and implicates both IL-23 and IL-12, key pro-inflammatory cytokines in the pathogenesis of Alzheimer’s disease. Importantly, it also demonstrates that in the APPPS1 Alzheimer’s disease mouse model, preventing the effects of these mediators, or ‘immune hormones’, with antibodies […]

Further Evidence That Prenatal Exposure to Stress May Increase the Risk of Asthma Development in Later Life

Further Evidence That Prenatal Exposure to Stress May Increase the Risk of Asthma Development in Later Life

A recent study published in the BioMed Research International journal suggests that maternal stress during pregnancy is able to increase offspring risk and susceptibility to asthma. Previous research indicates that prenatal and early-life stress can modify infant immune function in the long-term, including conferring a higher risk for childhood asthma (MK Pincus-Knackstedt et al., 2006; […]

New Evidence Indicates that Oxytocin Deficiency May Represent a Biomarker of Anxiety in Children

New Evidence Indicates that Oxytocin Deficiency May Represent a Biomarker of Anxiety in Children

A study by Karen Parker and her research team from the Stanford University School of Medicine links low levels of oxytocin with anxiety in children. Recent evidence indicates that oxytocin is an anxiolytic hormone, as it decreases the release of stress hormones, while oxytocin imbalances have been associated with both anxiety (HJ Lee et al., […]