News

A mix of news reporting on the latest developments in neuroendocrine-immunology & stress-immunity research

Stress May Start Driving Cardiovascular and Metabolic Risk Early In Life: Evidence from the 1958 British Birth Cohort Study

Stress May Start Driving Cardiovascular and Metabolic Risk Early In Life: Evidence from the 1958 British Birth Cohort Study

Ashley Winning et al. from the Harvard T.H. Chan School of Public Health, Boston, Massachusetts report in the the Journal of the the American College of Cardiology that psychological stress in childhood, adulthood or persistent across a person’s life can contribute to high cardiovascular and metabolic risk. Many clinical and epidemiological studies have documented the […]

New Evidence that Peripheral Nerves Sense Infection and Drive IL-23 Production by Skin Dendritic Cells

New Evidence that Peripheral Nerves Sense Infection and Drive IL-23 Production by Skin Dendritic Cells

In a new study published in the journal Immunity, Sakeen Kashem and colleagues from the University of Minnesota, Minneapolis, MN, USA report that in the murine skin, IL-23, derived from CD301b+ DCs drives IL-17A production by γδ T cells, and this cytokine network is required to establish resistance to cutaneous candidiasis. Interleukin (IL)-23 is a […]

Low Cortisol and Glucocorticoid Signaling But High Levels of Inflammation: Risk Factors for Developing Depression in Patients with Coronary Heart Diseases

Low Cortisol and Glucocorticoid Signaling But High Levels of Inflammation: Risk Factors for Developing Depression in Patients with Coronary Heart Diseases

A new Brain Behavior and Immunity study indicates that depression in coronary heart disease (CHD) is associated with high levels of inflammation in the context of low cortisol output and glucocorticoid receptor (GR) resistance. Coronary heart disease (CHD) and major depressive disorders (MDD) are among the major causes of disability in developed countries. There is […]

New Evidence That Psychological Stress Contributes To Peptic Ulcers Development

New Evidence That Psychological Stress Contributes To Peptic Ulcers Development

A new study published in the journal Clinical Gastroenterology and Hepatology provides new evidence that stress is related to an increased risk of peptic ulcers. Since the pioneering work of Hans Selye in the 1930s, psychological stress was often linked to the induction and progression of peptic ulcers. In the 1950s-60s, Selye began to promote […]

The Association of Body Composition and Novel Bioimpedance Measurements with Chronic Stress and Inflammation Biomarkers

The Association of Body Composition and Novel Bioimpedance Measurements with Chronic Stress and Inflammation Biomarkers

A recent study by Constantine Tsigos et al., published in the European Journal of Clinical Investigation (EJCI) indicates that the presence of ‘medically unexplainable symptoms’ (MUS) is an index of chronic stress and inflammation, and that advanced bioimpedance analysis may provide a useful, bloodless and rapid tool in the clinical setting. Chronic stress plays two […]

Vasoactive Intestinal Peptide Inhibits Pathogenic Th17 Cells from Rheumatoid Arthritis Patients

Vasoactive Intestinal Peptide Inhibits Pathogenic Th17 Cells from Rheumatoid Arthritis Patients

A study published in the Journal of Leukocyte Biology indicates that in blood from rheumatoid arthritis (RA) patients, vasoactive intestinal peptide (VIP) shifts the activity of T cells towards a more T regulatory cell phenotype, and reduces the pathogenic profile of T helper (Th)17 cells. The vasoactive intestinal peptide (VIP) is well-known for its immunoregulatory […]

Evidence for Small Fiber Neuropathy in the Cornea of Fibromyalgia Patients

Evidence for Small Fiber Neuropathy in the Cornea of Fibromyalgia Patients

A new study published in Seminars in Arthritis & Rheumatism indicates that in patients with fibromyalgia the density of small nerve fibers in the cornea is reduced, supporting an evolving concept that fibromyalgia is a small fiber neuropathy. Fibromyalgia is also considered a stress-related syndrome that affects predominantly women. Recent research suggests that fibromyalgia is […]

Cytokines Driving Sympathetic Nervous System Activation in the Subfornical Organ: Implications for Heart Failure and Hypertension

Cytokines Driving Sympathetic Nervous System Activation in the Subfornical Organ: Implications for Heart Failure and Hypertension

A recent study published in Hypertension demonstrates that cytokines such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α acting at the level of the subfornical organ induce the expression of inflammatory and excitatory mediators that subsequently drive sympathetic nervous system activation. The subfornical organ (SFO), a highly vascularized structure is a circumventricular organ that lacks […]

Vitamin D Deficiency May Contribute to the Reduction of Sympathetic and Sensory Innervation in Arthritis

Vitamin D Deficiency May Contribute to the Reduction of Sympathetic and Sensory Innervation in Arthritis

A new study published in Neuroscience demonstrates that vitamin D deficiency in experimental animals is related to sensory and sympathetic denervation and reduced neurotrophin levels in the synovium. Several studies have associated vitamin D levels with rheumatoid arthritis (RA) development in humans. Thus, low vitamin D levels are documented in patients with active RA. Also […]

Stress-Induced β2-Adrenoceptor-Mediated M2 Macrophage Polarization Promoting Tumor Growth in a Mouse Model of Breast Cancer

Stress-Induced β2-Adrenoceptor-Mediated M2 Macrophage Polarization Promoting Tumor Growth in a Mouse Model of Breast Cancer

A new study published in the BMB Reports indicates that stress hormones such as epinephrine (adrenaline) may promote the transformation of M1-type macrophages to M2-type macrophages and, thus, accelerate tumor growth in a mouse model of breast cancer. Several studies have linked psychological stress and breast cancer risk, associating with the involvement of stress mediators […]