Neuroendocrine Immunology News

Neuroendocrine immunology news on novel advances in the field bridging neurosciences and immunology

PACAP as an Intrinsic Regulator of Treg Abundance

PACAP as an Intrinsic Regulator of Treg Abundance

A study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) provides perhaps the first evidence that endogenous pituitary adenylyl cyclase-activating polypeptide (PACAP) modulates the production or expansion of regulatory T cells (Treg) and T helper (Th)17 lymphocytes. PACAP is a 38-amino-acid neuropeptide identified in 1989 from […]

Regulatory T Cells are Cerebroprotective in Acute Experimental Stroke

Regulatory T Cells are Cerebroprotective in Acute Experimental Stroke

A recent Nature Medicine study by Arthur Liesz et al. indicates that regulatory T cells (Treg) are cerebroprotective after experimental brain ischemia or stroke, and that interleukin (IL)-10 appears to be the major mediator of the cerebroprotective effects. Recent evidence indicates that inflammatory mechanisms such as up-regulation of pro-inflammatory cytokines and leukocytes’ invasion in the […]

Estrogens and Dendritic Cells

Estrogens and Dendritic Cells

A study published in the Journal of Immunology demonstrates that estrogens may boost innate immunity by enhancing interferon (IFN)-γ production by CD11c(+) cells. In humans, the sex differences or the sexual dimorphism in immune defense is a well-known phenomenon. Females have more vigorous cellular and humoral immune responses, and they are more resistant to infections […]