Neuroendocrine Immunology News

reports on new advances in the field

TRPV1 Sensory Nerves May Be Key to the Genesis of Airway Hyperreactivity in Experimental Asthma

TRPV1 Sensory Nerves May Be Key to the Genesis of Airway Hyperreactivity in Experimental Asthma

A new study in the Proceedings of the National Academy of Sciences (PNAS) of the USA implicates the transient receptor potential vanilloid 1 (TRPV1)-expressing sensory nerves in the pathogenesis of asthma and/or asthma attacks. The TRPV1 receptor, initially identified as the receptor for capsaicin, the hot component of chilli peppers, is typically expressed in sensory […]

Blocking IL-12 and IL-23 in APPPS1 Mouse Model Shows Promise as an Experimental Therapeutic Approach to Alzheimer’s Disease

Blocking IL-12 and IL-23 in APPPS1 Mouse Model Shows Promise as an Experimental Therapeutic Approach to Alzheimer’s Disease

A recent study, published in Nature Medicine is perhaps the first one to show interleukin (IL)-23 involvement, and implicates both IL-23 and IL-12, key pro-inflammatory cytokines in the pathogenesis of Alzheimer’s disease. Importantly, it also demonstrates that in the APPPS1 Alzheimer’s disease mouse model, preventing the effects of these mediators, or ‘immune hormones’, with antibodies […]

New Evidence Indicates that Oxytocin Deficiency May Represent a Biomarker of Anxiety in Children

New Evidence Indicates that Oxytocin Deficiency May Represent a Biomarker of Anxiety in Children

A study by Karen Parker and her research team from the Stanford University School of Medicine links low levels of oxytocin with anxiety in children. Recent evidence indicates that oxytocin is an anxiolytic hormone, as it decreases the release of stress hormones, while oxytocin imbalances have been associated with both anxiety (HJ Lee et al., […]

Vagus Nerve Stimulation Ameliorates Disease Activity in a Rodent Model of Rheumatoid Arthritis

Vagus Nerve Stimulation Ameliorates Disease Activity in a Rodent Model of Rheumatoid Arthritis

A study published in PLoS ONE is perhaps the first to demonstrate that electrical neurostimulation of the vagus nerve reduces signs of inflammation and disease severity in the collagen-induced arthritis (CIA), a disease model of rheumatoid arthritis in rodents. Previous research indicates that cholinergic signaling along the vagus nerve is able to affect the production […]

High Neonatal Monocyte Chemotactic Protein-1 (MCP-1) Levels May Represent an Early Marker of Autism

High Neonatal Monocyte Chemotactic Protein-1 (MCP-1) Levels May Represent an Early Marker of Autism

A study published in the Journal of Neuroinflammation indicates that the chemokine monocyte chemotactic protein-1 (MCP-1) may represent an early marker for ASD. Immune dysregulation and markers of inflammation have been associated with Autism Spectrum Disorder (ASD). Yet, most of the prior studies have used specimens taken after clinical diagnosis, and even with the relatively […]

The Combination of Cortisol Diurnal Variation, IL-6 and TNF-α as Potential Diagnostic Marker in Autism

The Combination of Cortisol Diurnal Variation, IL-6 and TNF-α as Potential Diagnostic Marker in Autism

A study published in the Research in Autism Spectrum Disorders Journal indicates that cortisol, IL-6 and TNF-α may become useful markers for autism spectrum disorder (ASD). At present, 1 in 68 children in the US, and 1 in 100, in the UK, develop ASD. This is approximately a 30% increase versus the previous estimates reported […]

Deficit of Oxytocin in Women with Major Depression

Deficit of Oxytocin in Women with Major Depression

A new study published in the Journal of Psychiatric Research extends the results of two previous studies and provides evidence that oxytocin levels are low in women with depression, including patients with psychotic major depression (PMD), who typically exhibit greater depressive severity. The neuropeptide oxytocin has been implicated in many aspects of reproductive and social […]

The TRPV1 Pain Receptor is Expressed and Functionally Active in Human T Lymphocytes

The TRPV1 Pain Receptor is Expressed and Functionally Active in Human T Lymphocytes

A study published in Nature Immunology reveals a previously unrecognized, ‘non-canonical’ role of the pain TRPV1 receptor – namely, its functional expression, and involvement in TCR signaling and pro-inflammatory activities of T cells. Transient receptor potential vanilloid type 1 ion channel (TRPV1), initially identified as the receptor for capsaicin (the hot ingredient of chilli peppers) […]

Hyperactive Type I Interferon System in the Choroid Plexus Linked To Aging and Cognitive Dysfunction

Hyperactive Type I Interferon System in the Choroid Plexus Linked To Aging and Cognitive Dysfunction

A study published in the August 21, 2014 issue of Science magazine demonstrates that aging is associated with an overactive IFN-I system at a specific brain structure, the choroid plexus. This vascular tissue, found in all cerebral ventricles, is an epithelial monolayer that forms the blood-cerebrospinal fluid barrier, and, in fact, represents the ‘interface’ between […]

Sympathetic Neuropathy Linked To the Development of Myeloproliferative Neoplasms

Sympathetic Neuropathy Linked To the Development of Myeloproliferative Neoplasms

A new study published in the August 07, 2014 issue of Nature magazine reveals that an impaired neuro-endocrine microenvironment of the bone marrow plays a crucial role in the development and clinical outcome of myeloproliferative neoplasms (MPNs). This and related studies may represent a breakthrough in hematology research and a paradigm shift in the MPNs’ […]