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Generalized Anxiety Disorder Linked to High IFN-γ and TNF-α but Low IL-10 Peripheral Levels

Generalized Anxiety Disorder Linked to High IFN-γ and TNF-α but Low IL-10 Peripheral Levels

A recent Brain, Behavior, and Immunity study provides perhaps the first evidence that Generalized Anxiety Disorder (GAD) is associated with a peripheral imbalance of pro- versus anti- inflammatory cytokines such as interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin (IL)-10. GAD, classified since the 1980s in the Diagnostic and Statistical Manual of Mental Disorder is […]

Psychoneuroimmunology Research Society 24th Annual Meeting Announcement

Psychoneuroimmunology Research Society 24th Annual Meeting Announcement

The PsychoNeuroImmunology Research Society (PNIRS) will hold its 24th annual meeting in Galveston, TX June 7-10, 2017.  Abstracts are being accepted through March 17, 2017.  Information regarding meeting registration and abstract submission can be found at https://www.pnirs.org/meetings/index.cfm. An exciting program is planned for PNIRS 2017 that will include a lecture by Dr. Carmine Pariante, winner […]

Meeting Announcement for the X Congress of the International Society for Neuroimmunomodulation

Meeting Announcement for the X Congress of the International Society for Neuroimmunomodulation

Dear colleagues, On behalf of the Organizing Committee, we cordially invite you to participate in The X Congress of the International Society for NeuroImmunoModulation (ISNIM), which this year is jointly organized with the III Congress of the Italian Society of Psycho-Neuro-Endocrine-Immunology (SIPNEI). The Congress will take place from 26th to 28th May 2017, in Rome, […]

Stress and Catecholamines Up-Regulate Proinflammatory Cytokine Production and Neutrophil Infiltration in Experimental Colitis

Stress and Catecholamines Up-Regulate Proinflammatory Cytokine Production and Neutrophil Infiltration in Experimental Colitis

A recent Brain, Behavior and Immunity study indicates that psychological stress contributes to the exacerbation of the murine model of colitis by promoting the mobilization and entry of neutrophils in the colon. This appears to be achieved by the up-regulation of pro-inflammatory cytokine and chemokine production and STAT3 signaling, and involves β1/β2-adrenergic receptors activation. Inflammatory […]

Promotional Offer – BrainImmune: Trends in Neuroendocrine Immunology

Promotional Offer – BrainImmune: Trends in Neuroendocrine Immunology

Promotional Offer & Partnering with BrainImmune: We are offering one month free advertising space to institutions that sign up for a 6 month sponsorship/partnership contract, and 3 months free ad space upon signing of one year contract. For more information, see our Sponsorship opportunities page. BrainImmune: Trends in Neuroendocrine Immunology is the first online resource […]

Glucocorticoid-Resistant IL-17- and IL-22-secreting CD4+ T Cells May Contribute to Increased Disease Activity in Multiple Sclerosis

Glucocorticoid-Resistant IL-17- and IL-22-secreting CD4+ T Cells May Contribute to Increased Disease Activity in Multiple Sclerosis

A recent study published in Immunology is perhaps the first to demonstrate a correlation between the production of interleukin (IL)-17 and IL-22, and its glucocorticoid resistance, and the number of active brain lesions in multiple sclerosis (MS). Increased active brain lesions were found in patients whose IL-17- and IL-22-producing T cells were more resistant to […]

First Evidence that Meningeal Interferon-γ Affects Neuronal Connectivity and Social Behavior

First Evidence that Meningeal Interferon-γ Affects Neuronal Connectivity and Social Behavior

A recent study published in Nature magazine links the meningeal immunity to the regulation of social behavior, implicating the meningeal interferon (IFN)-γ and its modulatory effects on the activity of brain cortex GABAergic neurons. Diseases such as autism spectrum disorder, frontotemporal dementia and schizophrenia are characterized by severe social and immune dysfunction. Little is known […]

Chronic Stress Induces Shrinkage of Medial Amygdala Neurons in Mice: Recovery by the Fast-Acting Candidate Antidepressant Acetyl-L-Carnitine

Chronic Stress Induces Shrinkage of Medial Amygdala Neurons in Mice: Recovery by the Fast-Acting Candidate Antidepressant Acetyl-L-Carnitine

A recent study in Molecular Psychiatry provides new evidence that chronic stress generates structural remodelling of the brain amygdala, and particularly the shrinkage of medial amygdala neurons in mice. Chronic stress has been linked to cognitive impairment, but it is also known that stress modifies the neuronal architecture in several brain cognitive areas. However, little […]

Deficiency of Stress Resilience in Late Adolescence Linked To Increased Risk of Hypertension in Adulthood

Deficiency of Stress Resilience in Late Adolescence Linked To Increased Risk of Hypertension in Adulthood

A new study published in the journal Heart indicates that men with low stress resilience during youth are prone to approximately 40% increase in the risk of developing hypertension in later life. Of note, the combination of low stress resilience and high body mass index (BMI) triples the hypertension risk. High blood pressure is a […]

Norepinephrine May Shift the IL-12/IL-23 Ratio of Dendritic Cells towards IL-23 Predominance thus Favoring Th17 Differentiation

Norepinephrine May Shift the IL-12/IL-23 Ratio of Dendritic Cells towards IL-23 Predominance thus Favoring Th17 Differentiation

A new study published in the January 15, 2016 issue of the Journal of Immunology indicates that in murine bone marrow–derived dendritic cells (DCs), norepinephrine, via stimulation of β2-adrenoceptors, is able to promote a shift in the IL-12p70/IL-23 cytokine ratio. Primary and secondary lymphoid organs receive a rich autonomic nervous system innervation, mainly by the […]

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