Cytokines and Brain Functions

BrainImmune short overviews in this research area

Disruption of Brain TNF Homeostasis Elicits Maladaptive Alterations Producing Chronic Pain

Disruption of Brain TNF Homeostasis Elicits Maladaptive Alterations Producing Chronic Pain

Overview article We have determined that enhanced expression of the pro-inflammatory cytokine Tumor Necrosis Factor (TNF)-α by both neurons and glial cells of the brain direct the process involved with the development and also the maintenance of neuropathic pain. However, TNF is not only a pro-inflammatory cytokine but is also a potent neuromodulator. TNF specially […]

T Cell and Antigen Presenting Cell Activity During Sleep

T Cell and Antigen Presenting Cell Activity During Sleep

Overview article Sleep supports immune defense. In the first half of nocturnal sleep, slow wave sleep (SWS) and the circadian system act in concert to induce a pro-inflammatory milieu, while immunosuppressive mediators are at lowest levels. This pro-inflammatory milieu boost and facilitates T helper (Th) 1 immune responses, like an adjuvant. On the other side, […]

Interferon and the Central Nervous System

Interferon and the Central Nervous System

Overview article Interferons (IFNs) are glycoproteins known as cytokines. These cytokines got their name by Isaacs and Lindenmann [1] after their ability to interfere with viral growth and production. Isaacs and Lindenmann worked at the Medical Research Council Laboratory in Mill Hill, outside London and were the first to publish a paper on these proteins. […]

Brain-Immune Signaling: Focus on Pathogen Recognition and PGE2 Synthesis

Brain-Immune Signaling: Focus on Pathogen Recognition and PGE2 Synthesis

Overview article The body’s reaction to infections involves the orchestration of multiple systems to effectively initiate, execute and resolve the immune response. At the core of these adaptive processes are the cellular and molecular neural, immune and endocrine interactions that begin with the central nervous system recognizing the presence of an infection. The mediator prostaglandin […]