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The official blog of BrainImmune.com

Massage May Affect Immunity via the Sympathetic Innervation and Noradrenaline Release

Massage May Affect Immunity via the Sympathetic Innervation and Noradrenaline Release

Fulvio D`Acquisto and colleagues from Queen Mary University of London, UK recently showed that 8 days of massage-like therapy (hand- but not brush-stroked mice) resulted in modulation of murine immune system’s parameters through the sympathetic innervation and noradrenaline release. Massage per se apparently had no effect on anxiety-like behaviors in mice, but the immunomodulatory effects […]

Colchicine May Prove Useful In the Treatment of Acute Coronary Syndrome

Colchicine May Prove Useful In the Treatment of Acute Coronary Syndrome

A study by Gonzalo Martınez et al., published in the Journal of the American Heart Association indicates that colchicine may also be useful for the treatment of heart attacks by reducing cardiac inflammation and the local pro-inflammatory cytokine production. Colchicine is an alkaloid with potent anti-inflammatory effects, which is often used for the treatment of […]

Early Childhood Farm Environment Exposure Inducing T Helper 1-Cytokine Profiles and Asthma Protection?

Early Childhood Farm Environment Exposure Inducing T Helper 1-Cytokine Profiles and Asthma Protection?

In a recent study by Heidi Kääriö et al., using samples from the Protection Against Allergy-Study in Rural Environments (PASTURE) birth cohort, demonstrate that farm exposures (stables, hay barn, farm milk) at age 4.5 years is linked to amplified Th1-type cytokine production. The research group from Finland and Germany report that peripheral blood mononuclear cells […]

High Levels of the Pro-Inflammatory Cytokines IL-1β and IL-6 Found in Patients with Suicidality

High Levels of the Pro-Inflammatory Cytokines IL-1β and IL-6 Found in Patients with Suicidality

A recent  study published in the journal Biological Psychiatry indicates the presence of aberrant cytokine levels in patients with suicidality, and identifies a link between pro-inflammatory cytokines, and specifically, interleukin (IL)-1β and IL-6 with suicidal behavior. Previous research has shown that major depression is associated with an immune response with an increased production of pro-inflammatory […]

Sex and Stem cells

Sex and Stem cells

A new study in Cell Stem Cell, discusses the “sexual dimorphism of longevity”, wherein most of supercentenarians are female, linking this to increased stem cell self-renewal and regeneration potential in females. Of note, out of the 53 living supercentenarians – human individuals currently living over the age of 110 – 51 are female, and sexual […]

Further Evidence That the Cytokine GM-CSF is an Essential Factor in the Pathogenesis of Multiple Sclerosis

Further Evidence That the Cytokine GM-CSF is an Essential Factor in the Pathogenesis of Multiple Sclerosis

Rasouli et al., published in the June 1st issue of the Journal of Immunology reports that treatment-naive MS patients had greater numbers of GM-CSF+ T cells in the peripheral blood, whereas CD4+ and CD8+ T cells in MS brain lesions expressed GM-CSF. In addition, interferon (INF)-β suppressed GM-CSF production by T cells, in vitro conditions. […]

Tumor Necrosis Factor Modulates Bitter Taste Responses

Tumor Necrosis Factor Modulates Bitter Taste Responses

A new study by Pu Feng and colleagues from the Monell Chemical Senses Center, Philadelphia, USA, published in Brain, Behavior, and Immunity indicates that tumor necrosis factor (TNF)-α, a major pro-inflammatory cytokine is involved in the regulation of bitter taste reception. Whether inflammatory cytokines contribute to taste reception or regulation is poorly understood. TNF is […]

New Function for Prolactin: Involvement in Sexual Behavior, Pair-Bonding and Infant Care

New Function for Prolactin: Involvement in Sexual Behavior, Pair-Bonding and Infant Care

Prolactin is well-known for its role in stimulating milk production in nursing mothers but a new study published in the online journal PLoS One identifies a previously unrecognized function of this hormone – its contribution to sexual behavior and pair-bonding. The study used cotton-top tamarins, a socially-monogamous, small monkey native to Colombia that live in […]

Optimism Linked To Better Cardiovascular Health

Optimism Linked To Better Cardiovascular Health

Rosalba Hernandez and colleagues from the University of Illinois at Urbana–Champaign, IL recently reported a link between optimism and cardiovascular health, derived from a large, ethnically and racially diverse population study, being perhaps the first in this field. Begun in 2000, the Multi-Ethnic Study of Atherosclerosis (MESA) included 6,000 people from six U.S. regions, followed […]

Deficiency of IL-10 in Chronic Fatigue Syndrome?

Deficiency of IL-10 in Chronic Fatigue Syndrome?

A new 2015 study, published in the Mediators of Inflammation journal suggests a deficiency of interleukin (IL)-10 in chronic fatigue syndrome (CFS). Chronic fatigue syndrome/myalgic encephalomyelitis, an illness characterized by unexplained fatigue lasting 6 months or more, is often linked to dysfunctional neuroendocrine and immune responses, including abnormal production of several cytokines (NG Klimas & […]