Melatonin May Control the Balance between Pathogenic Th17 and Regulatory T Cells

Melatonin May Control the Balance between Pathogenic Th17 and Regulatory T Cells

COMMENTARY ARTICLE on the study by Mauricio Farez et al., 2015, Cell, 162, 1338–1352 Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses‘ The central master circadian clock is located in the suprachiasmatic nucleus (SCN). The output of this system is synchronized to 24 hours by the light-dark cycle. The SCN regulates rhythms in peripheral cells […]

Psychological Stress May Promote Inflammation through Expansion of Immature Proinflammatory Monocytes

Psychological Stress May Promote Inflammation through Expansion of Immature Proinflammatory Monocytes

A recent study by Nicole Powell et al. published in the October 8, 2013 issue of PNAS, suggests that stress hormones may contribute to pro-inflammation through selective expansion and/or recruitment of a specific subpopulation of immature, proinflammatory monocytes. In the 1970s and 1980s stress was often considered immunosuppressive. Recent evidence, however, indicates that psychological stress […]

Mainstream Immunology Research and Cultural Separation

Mainstream Immunology Research and Cultural Separation

EDITORIALS & OPINIONS One of the curious aspects of modern biomedicine is the “cultural separation” of immunology research from neurobiology and physiology research. One can argue that the failure to link the immune system to the brain (and vice versa) has played a role in the immunology’s minimal progress from the bench to the bedside […]