Inhibitors of RORγt Targeting Th17 Cells May Hold Promising Therapeutic Potential in Inflammation & Autoimmunity

Inhibitors of RORγt Targeting Th17 Cells May Hold Promising Therapeutic Potential in Inflammation & Autoimmunity

Recently, several RORγt inhibitors have been identified that effectively restrict the function and differentiation of pro-inflammatory T helper (Th)17 cells. The transcription factor RORγt belongs to the nuclear receptor superfamily – consisting of 48 members that serve as ligand-activated transcription factors translating extracellular or intracellular signals into a transcriptional response. RORγt is the immune cell-specific […]

Sympathetic Nerves Keep Up an Anti-Inflammatory State by Inhibiting Macrophage TNF-α Expression in Fat Tissue

Sympathetic Nerves Keep Up an Anti-Inflammatory State by Inhibiting Macrophage TNF-α Expression in Fat Tissue

New report, published in Endocrinology, implicates the activity of the sympathetic nervous system (SNS) and its β2-adrenoceptor signaling pathway in sustaining at low levels the production of the pro-inflammatory cytokine tumor necrosis factor (TNF)-α in macrophages of lean mice. Pro-inflammatory macrophages play a key role in the pathogenesis of the systemic low-grade chronic inflammation, associated […]

More Evidence that Norepinephrine and β3-Adrenoreceptors May Drive Melanoma Progression & Aggressiveness

More Evidence that Norepinephrine and β3-Adrenoreceptors May Drive Melanoma Progression & Aggressiveness

A report recently published in Oncotarget shows that the β3-adrenoreceptors are involved in melanoma aggressiveness, and that these receptors, expressed on several accessory cells, may orchestrate their function and thus, sustain melanoma progression. Recent research indicates that stress and stress mediators contribute to cancer development and/or progression. It appears that in this process a major […]

Stress May Start Driving Cardiovascular and Metabolic Risk Early In Life: Evidence from the 1958 British Birth Cohort Study

Stress May Start Driving Cardiovascular and Metabolic Risk Early In Life: Evidence from the 1958 British Birth Cohort Study

Ashley Winning et al. from the Harvard T.H. Chan School of Public Health, Boston, Massachusetts report in the the Journal of the the American College of Cardiology that psychological stress in childhood, adulthood or persistent across a person’s life can contribute to high cardiovascular and metabolic risk. Many clinical and epidemiological studies have documented the […]

New Evidence that Stress May Increase the Risk of Developing Dementia and Alzheimer’s: the Einstein Aging Study

New Evidence that Stress May Increase the Risk of Developing Dementia and Alzheimer’s: the Einstein Aging Study

According to a recent report published in the journal Alzheimer Disease & Associated Disorders stress may increase up to 30% the risk of developing amnestic mild cognitive impairment (aMCI) or dementia. Mild cognitive impairment is a significant risk factor for the development of dementia and Alzheimer’s disease. Moreover, among all MCI subtypes, patients with amnestic […]

Stress May Contribute To Male Infertility by Affecting Sperm Concentration, Motility and Morphology

Stress May Contribute To Male Infertility by Affecting Sperm Concentration, Motility and Morphology

A recent study, published in the journal Fertility and Sterility, indicates that perceived stress and stressful life events, but not work-related stress, are associated with semen quality such as sperm concentration, motility and morphology. According to a recent review article in Nature Reviews Urology a close relationship seems to exist between the testes and the […]

Th17 and Th22 Cells May Contribute To the Pathogenesis of Guillain-Barré Syndrome

Th17 and Th22 Cells May Contribute To the Pathogenesis of Guillain-Barré Syndrome

A study by Shujuan Li and colleagues from the Jilin University, Changchun, China, suggests that Th17 and Th22 cells might be involved in the onset and development of Guillain-Barré Syndrome. T helper (Th)17 cells and the interleukin (IL)-23→IL-17 axis drive chronic inflammation in many autoimmune diseases. The report by Li et al, published in the […]

Personality Traits like Extraversion and Conscientiousness Linked to Pro-Inflammatory Genes Expression

Personality Traits like Extraversion and Conscientiousness Linked to Pro-Inflammatory Genes Expression

A study published in the journal Psychoneuroendocrinology demonstrates that leukocyte gene expression correlates with two major dimensions of human personality, extraversion and conscientiousness. A recent study in nonhuman primates provides new insights into the neuroanatomical basis of personality, showing that personality traits are linked to the anatomy of specific brain structures such as the anterior […]

An Association between Widespread Pain and Serum IL-8 Levels in Fibromyalgia Patients

An Association between Widespread Pain and Serum IL-8 Levels in Fibromyalgia Patients

Ozdolap S, et al. recently reported, at the European League against Rheumatism Annual European Congress of Rheumatology, June 10-13, 2015, a positive correlation between widespread pain and serum IL-8 in patients with fibromyalgia (FM). This substantiates previous work indicating that the pro-inflammatory chemokine IL-8 may contribute to the pathogenesis of fibromyalgia (Wang H. et al., […]

First Evidence that IL-9 Contributes to Atherosclerosis Development

First Evidence that IL-9 Contributes to Atherosclerosis Development

Perhaps the first evidence for an involvement of IL-9 in atherosclerosis was recently reported in the online journal PLoS One by Ida Gregersen and colleagues from the Oslo University Hospital Rikshospitalet, Oslo, Norway. Interleukin (IL)-9 is a cytokine linked mostly to T helper (Th)2 cell responses and Th2-related conditions such as parasitic helminth infections and […]