Gerald Weissmann, Meryl Streep, Mechnikov and Inflammation: It’s Complicated

Gerald Weissmann, Meryl Streep, Mechnikov and Inflammation: It’s Complicated

SHORT FEATURES and FACES ARTICLE In a recent Editorial, Gerald Weissmann, in his typical elegant and provocative style, mingles Hollywood stars and movie characters with some major pathology phenomena. The recent movie ‘It’s Complicated’ inspired the Editor-in-Chief of the FASEB journal to find some striking similarities between some of the movie’s features and the cardinal […]

Beta Blockers Hold Substantial Potential for Therapeutical Interventions in Cancer

Beta Blockers Hold Substantial Potential for Therapeutical Interventions in Cancer

Evolving Concepts Recently, more than 10 studies [see References 1-11], published in the last 3-4 years indicate the presence of high intratumoral concentrations of catecholamines and that these neurohormonal mediators affect key components of tumor biology such as tumor growth, angiogenesis, and migration or invasion [for details see References 12-13]. These studies suggest that blocking […]

Celebrities, Stress and Cancer

Celebrities, Stress and Cancer

SHORT FEATURES and FACES ARTICLE Recently, several websites have reported that Michael Douglas has been diagnosed with throat cancer. The actor believes a combination of his previous hard-driving lifestyle and the stresses of the past 12 months may have caused the cancer. He tells UK’s Daily Mirror that stress was a major factor: “This type […]

Stress Response, Sex and Immunity: the Female Superiority

Stress Response, Sex and Immunity: the Female Superiority

SHORT FEATURES and FACES ARTICLE A recent perspective published in Science Signaling outlines the gender-specific differences in the stress response and the actions of glucocorticoids, and the female superiority in terms of dealing with stress and infections. Sexual dimorphism in immunity, i.e. the differences in males and females in their immunological responses and immune function […]

The Stress-Susceptible Individual and the Risk for Inflammatory Diseases

The Stress-Susceptible Individual and the Risk for Inflammatory Diseases

SHORT FEATURES and FACES ARTICLE In this recent editorial Gailen Marshall, Editor-in-Chief of Annals of Allergy, Asthma & Immunology, discusses the topic of identifying and stratifying stress-susceptible individuals and established patients, and the relevance of correlating this susceptibility to the presence and/or progression of immune-mediated inflammatory conditions. An increasing body of evidence suggests stress is […]

Stress and Rheumatic Diseases

Stress and Rheumatic Diseases

SHORT FEATURES and FACES ARTICLE In an editorial published in Arthritis Research & Therapy, Afton Hassett and Daniel Clauw, of University of Michigan Medical School, discuss some aspects of the complex interactions between psychological stress and the onset, expression and progression of rheumatic diseases. The authors mention that some studies in this research area are […]

Bridging Neurosciences and Immunology – An Overview

Bridging Neurosciences and Immunology – An Overview

Historical Perspectives The brain and the immune system, or the “supersystems”, a term coined by Tomio Tada (1997), are the two major adaptive systems of the body. Although the immune system has been often regarded as autonomous, the evidence accumulated over several decades indicates that the central nervous system (CNS) receives messages from the immune […]