Antibiotics through Effects on the Microbiota-Gut-Brain Axis and Inflammatory Monocytes May Reshape Brain Hippocampal Neurogenesis

Antibiotics through Effects on the Microbiota-Gut-Brain Axis and Inflammatory Monocytes May Reshape Brain Hippocampal Neurogenesis

A new Cell Reports study indicates that ‘inflammatory’ monocytes may represent the missing ‘pathogenic link’ between the antibiotics’ effects on gut microbiota, and the subsequent changes in the brain hippocampal neurogenesis and plasticity. Recent research suggests that antibiotics may exert some of their unsolicited side effects through effects on the gut-brain axis. Soon after birth, […]

Gut and Gingival Bacteria: Game Changers or Innocent Bystanders in Rheumatoid Arthritis?

Gut and Gingival Bacteria: Game Changers or Innocent Bystanders in Rheumatoid Arthritis?

Several publications in the last 2-3 years brought more interest in the link between gut and gingival bacteria or microbiota, and human health and diseases, and particularly their possible game changer role in the pathogenesis of rheumatoid arthritis. The human gastrointestinal tract comprises approximately 1014 bacterial microbes and amounts to a biomass of approximately 2 […]

IL-35 Contributing to Immune Tolerance in Normal Pregnancy

IL-35 Contributing to Immune Tolerance in Normal Pregnancy

A study published in PLoS One indicates that normal pregnancy is associated with increased levels of interleukin (IL)-35, whereas recurrent spontaneous abortions are linked to low levels of this cytokine, suggesting the involvement of IL-35 in the maintenance of immune tolerance during pregnancy. IL-35, identified in 2007 is a major immunosuppressive and anti-inflammatory cytokine along […]

Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma

Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma

A recent Journal of Translational Medicine study indicates that interleukin (IL)-33 is produced by bronchial smooth muscle cells (BSMCs) upon rhinovirus (RV) infection and activation of TLR3, and that this response is associated and/or mediated by ATP released by viral-stimulated BSMCs. IL-33 is a cytokine constitutively expressed in epithelial barrier tissues, and was originally described […]

The Therapeutic Potential of Secukinumab in Rheumatic Diseases

The Therapeutic Potential of Secukinumab in Rheumatic Diseases

A review by Marije Koenders in Drug Design, Development and Therapy outlines some major features and characteristics of the new biological Secukinumab, which blocks the actions of interleukin 17A (IL-17), and explores its development, therapeutic potential and use in several rheumatic diseases. IL-17 provides protection against extracellular bacterial and fungal infections. However, IL-17 and Th17 […]

Job Burnout Reaching an Unprecedented Level and Half of US Physicians Experiencing Professional Burnout

Job Burnout Reaching an Unprecedented Level and Half of US Physicians Experiencing Professional Burnout

According to a recent Fast Company article, job burnout, in general, is reaching an unprecedented level, and as per a January 2017  Mayo Clinic Proceedings report “50% of US physicians are experiencing professional burnout”. Burnout syndrome is mostly a work-related condition and the subject’s response to chronic work-related stress. According to the classical definition, this […]

New Evidence Linking IL-17 to Neuropathic Pain

New Evidence Linking IL-17 to Neuropathic Pain

A study published in Molecular Medicine Reports provides further evidence that interleukin (IL)-17 contributes to neuropathic pain through the activation of astrocytes and secretion of proinflammatory cytokines. Neuropathic pain or chronic pain is a disease syndrome caused by injury to peripheral nerves, the spinal cord or the brain and over 1.5 billion people suffer from […]

Hans Selye and the 80th Birthday of Stress Research

Hans Selye and the 80th Birthday of Stress Research

Stress research has been around for 80 years but has perhaps never been more actual and trendy as in recent years. The term ‘stress’ (psychological) is extremely popular and the general public, as well as celebrities, frequently use and occasionally abuse this term to describe situations causing agitation or alteration of their wellbeing. In PubMed, […]

Sympathetic Nerves via β2-adrenoceptor Signaling Generate Circadian Rhythms and Govern Lymphocyte Recirculation in Lymph Nodes

Sympathetic Nerves via β2-adrenoceptor Signaling Generate Circadian Rhythms and Govern Lymphocyte Recirculation in Lymph Nodes

A new study, published in the Journal of Experimental Medicine (JEM), indicates that in mice, the sympathetic nervous system (SNS) innervation, through β2-adrenergic receptors activation controls the circadian dynamics and traffic of lymphocytes through the lymph nodes (LNs). Both primary and secondary lymphoid organs are heavily innervated, mostly by the peripheral sympathetic nerves. Thus, locally […]

Aducanumab Shows Promise and Impressive Effects in Reducing Alzheimer’s Amyloid-β Plaques

Aducanumab Shows Promise and Impressive Effects in Reducing Alzheimer’s Amyloid-β Plaques

A study recently published in the journal Nature indicates that aducanumab shows promise, in both preclinical and clinical settings, in prevention and reduction of amyloid-β (Aβ) plaques in patients with Alzheimer’s. Aducanumab is a recombinant human monoclonal antibody targeting Aβ aggregates that are believed to play a critical role in the neurodegenerative Alzheimer’s process. Previous […]

Page 1 of 16123Next ›Last »