Pro-Inflammatory Th17 Cells and Glucocorticoid Resistance: Implications for Chronic Inflammatory Diseases and Their Treatment

Pro-Inflammatory Th17 Cells and Glucocorticoid Resistance: Implications for Chronic Inflammatory Diseases and Their Treatment

Evolving Concepts Summary Th17 cells have heterogeneous phenotypes and functions, and can have pro- or anti-inflammatory activities. Pathogenic Th17 cells have been associated to several inflammatory and autoimmune diseases. Besides IL-17A and IL-17F, they also produce GM-CSF and IFN-γ, and express high levels of IL-23R. These cells are refractory to glucocorticoid (GC)-mediated T cell suppression, […]

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

Commentary on the study by George Schett et al, Nat Med, 2013 Jul;19(7):822-4 How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy Extensive genome-wide association and epidemiological studies have shed light on the causes of chronic inflammatory diseases and have confirmed a central role of the immune system and particularly of cytokines [1]. Secreted […]