Sympathetic Nerves Keep Up an Anti-Inflammatory State by Inhibiting Macrophage TNF-α Expression in Fat Tissue

Sympathetic Nerves Keep Up an Anti-Inflammatory State by Inhibiting Macrophage TNF-α Expression in Fat Tissue

New report, published in Endocrinology, implicates the activity of the sympathetic nervous system (SNS) and its β2-adrenoceptor signaling pathway in sustaining at low levels the production of the pro-inflammatory cytokine tumor necrosis factor (TNF)-α in macrophages of lean mice. Pro-inflammatory macrophages play a key role in the pathogenesis of the systemic low-grade chronic inflammation, associated […]

Anxiety, Depression and Obesity May Jointly Contribute To Asthma Development

Anxiety, Depression and Obesity May Jointly Contribute To Asthma Development

A recent study by M. Brumpton et al., published in the International Journal of Epidemiology has shed light on the complex interactions and joint effects of anxiety, depression and obesity on the onset and development of asthma. Approximately 300 million people suffer from asthma, amounting to nearly 1% of the total global disease burden, worldwide. […]

Childhood Adversities and the Development of Asthma in Adulthood

Childhood Adversities and the Development of Asthma in Adulthood

Recently the BMJ Open online journal published the first large-scale prospective, population-based study, involving 24 057 participants, followed for a 7-year period, documenting an association between childhood adversities and register-verified asthma diagnosis in adulthood. Previous research has shown that anxiety disorders and major depression are linked to asthma development, and two previous longitudinal studies reported […]

Large Population Study Links Stress in Middle Age Women to Dementia and Alzheimer’s Risk Decades Later

Large Population Study Links Stress in Middle Age Women to Dementia and Alzheimer’s Risk Decades Later

A Swedish study, published in the August 2013 online issue of BMJ Open indicates that a higher number of psychosocial stressors in middle-aged women were associated with increased risk of dementia and Alzheimer’s disease (AD) decades later in life. This is perhaps the first population study on the relationship between midlife stressors and increased risk […]

Combat-training stress and high pro-inflammatory markers in soldiers linked to increased intestinal permeability and gastrointestinal symptoms

Combat-training stress and high pro-inflammatory markers in soldiers linked to increased intestinal permeability and gastrointestinal symptoms

A study published in the February 2013 issue of Alimentary Pharmacology and Therapeutics reports that soldiers participating in as little as 6 weeks of combat training had high stress; anxiety and depression levels combined with gastrointestinal (GI) symptoms, pro-inflammatory immune activation and increased intestinal permeability. Gastrointestinal symptoms in soldiers are among the most common causes […]