Lifetime Adversity Is Associated With Inflammation and Elevated CRP Levels

Lifetime Adversity Is Associated With Inflammation and Elevated CRP Levels

A recent study published in Brain, Behavior and Immunity suggests that adversity during childhood and trauma during adulthood are associated with elevated high sensitivity C-reactive protein (hsCRP). This is perhaps the first large population-based study to assess the connection between adulthood trauma exposure and inflammation. Over 11,000 adults ranging from age 59 to 79 years […]

Sex and Stem cells

Sex and Stem cells

A new study in Cell Stem Cell, discusses the “sexual dimorphism of longevity”, wherein most of supercentenarians are female, linking this to increased stem cell self-renewal and regeneration potential in females. Of note, out of the 53 living supercentenarians – human individuals currently living over the age of 110 – 51 are female, and sexual […]

Magnified Peripheral IL-6 Response Linked To Stress Susceptibility and Higher Risk of Depression

Magnified Peripheral IL-6 Response Linked To Stress Susceptibility and Higher Risk of Depression

A new study published in the Proceedings of the National Academy of Sciences of the USA is perhaps the first to demonstrate that the magnitude of peripheral interleukin (IL)-6 responses preceding stress challenge may confer inter-individual differences in susceptibility or resilience to a subsequent social stressor. Previous research indicates that in humans both major depression […]

Lena Johansson, Stress and Alzheimer’s Risk in Women

Lena Johansson, Stress and Alzheimer’s Risk in Women

SHORT FEATURES and FACES ARTICLE In this recent editorial, Lena Johansson outlines some current concepts and research trends related to the long terms effects of stress and their impact on risk and development of Alzheimer’s disease (AD) in women. Dr. Johansson has authored two population studies – perhaps the first in this area – on […]

Perispinal Etanercept Improves Neurological Function in Chronic Brain Injury

Perispinal Etanercept Improves Neurological Function in Chronic Brain Injury

A new case report by Tobinick et al. in the May 2014 issue of Clinical Drug Investigation describes striking success with a single perispinal etanercept dose in a patient who sustained brain injury 3 years prior. Multiple reports have shown promise for use of etanercept, a tumor necrosis factor (TNF) inhibitor, in patients with chronic […]

Pro- and Anti-Inflammatory Effects of Neuropeptide Y: Induction of Dendritic Cells Migration and Th2 Polarization

Pro- and Anti-Inflammatory Effects of Neuropeptide Y: Induction of Dendritic Cells Migration and Th2 Polarization

A new study in The FASEB Journal indicates that Neuropeptide Y (NPY) is able to promote migration of human monocyte-derived immature dendritic cells (DCs), and a T helper (Th)2 polarization. NPY is a neurotransmitter released by the sympathetic nervous system along with norepinephrine (noradrenaline), and elevated NPY levels are detected in conditions of acute or […]

Viruses and Glucocorticoids ‘Cooperate’ to Induce Interleukin-10 Production: Implications for Stress-Induced Immunosuppression and Exacerbations of Asthma

Viruses and Glucocorticoids ‘Cooperate’ to Induce Interleukin-10 Production: Implications for Stress-Induced Immunosuppression and Exacerbations of Asthma

A study published in the May 2013 issue of PLoS One may indicate a novel, unrecognized interaction between viruses and the glucocorticoid (GC)-signaling system that results in the induction of interleukin (IL)-10 production by dendritic cells (DCs). In this report, Sinnie Ng and colleagues from the National Institutes of Child Health and Human Development, and […]

Accumulation of Myeloid-Derived Suppressor Cells: A New Mechanism in Favor of Stress-Induced Immunosuppression?

Accumulation of Myeloid-Derived Suppressor Cells: A New Mechanism in Favor of Stress-Induced Immunosuppression?

Jianfeng Jin et al. present a mechanism for the immunosuppressive potential of chronic stress in the September 2013 issue of PLoS One. The authors focus on myeloid-derived suppressor cells (MDSCs), which have been implicated in regulation of the innate and adaptive immune responses. In tumor microenvironments, MDSC expansion is stimulated by prostaglandin E2 (PGE2) and […]

Stress and Worrying Affect Short-Term Fluctuations in Rheumatoid Arthritis Symptoms

Stress and Worrying Affect Short-Term Fluctuations in Rheumatoid Arthritis Symptoms

In the July 2013 issue of Annals of Rheumatic Diseases, Evers et al. report that stress and worrying predict indicators of rheumatoid arthritis disease activity such as fatigue and pain. Psychological stress has been linked to the onset and course of rheumatoid arthritis (RA). While for the juvenile chronic arthritis (JCA), chronic stress appear to […]

Evidence that electroacupuncture affects immunity through a specific dopaminergic neuroendocrine pathway

Evidence that electroacupuncture affects immunity through a specific dopaminergic neuroendocrine pathway

A new study, published in the February 23, 2014 issue of Nature Medicine (Advance Online Publication) provides perhaps the first robust evidence that acupuncture’s effects are translated through specific neuroendocrine and immune pathways. The way acupuncture affects human physiologic processes, and particularly immune function and homeostasis, is not well understood. Acupuncture has always been considered […]

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