β2-Adrenergic Receptor Activation Promotes M2 Polarization of Gut Macrophages: How the Brain–Gut Axis Maintains Tissue Homeostasis

β2-Adrenergic Receptor Activation Promotes M2 Polarization of Gut Macrophages: How the Brain–Gut Axis Maintains Tissue Homeostasis

COMMENTARY ARTICLE on the study by Ilana Gabanyi et al, Cell, 2016 164, 378-391 Neuro-Immune Interactions Drive Tissue Programming in Intestinal Macrophages A new study published in the journal Cell indicates that tissue macrophages located in different regions of the gut, exhibit a high degree of specialization and form a cellular network with enteric neurons. […]

New Evidence that Peripheral Nerves Sense Infection and Drive IL-23 Production by Skin Dendritic Cells

New Evidence that Peripheral Nerves Sense Infection and Drive IL-23 Production by Skin Dendritic Cells

In a new study published in the journal Immunity, Sakeen Kashem and colleagues from the University of Minnesota, Minneapolis, MN, USA report that in the murine skin, IL-23, derived from CD301b+ DCs drives IL-17A production by γδ T cells, and this cytokine network is required to establish resistance to cutaneous candidiasis. Interleukin (IL)-23 is a […]

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

COMMENTARY ARTICLE on the study by George Schett et al, Nat Med, 2013 Jul;19(7):822-4 How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy Extensive genome-wide association and epidemiological studies have shed light on the causes of chronic inflammatory diseases and have confirmed a central role of the immune system and particularly of cytokines [1]. […]