The Neuroimmune Biology of Vasopressin

The Neuroimmune Biology of Vasopressin

Overview article Vasopressin (VP) has emerged in recent years as a very important immunoregulatory peptide of the hypothalamus. VP is capable of maintaining immune function, both innate and adaptive immunity. This is due to the ability of VP to stimulate both the hypothalamic-pituitary-adrenal (HPA) axis and prolactin (PRL) secretion. The HPA axis is important for […]

Hans Selye and the Birth of the Stress Concept

Hans Selye and the Birth of the Stress Concept

Historical Perspectives In 1936 a half page report appeared in Nature magazine under the title “A syndrome produced by diverse nocuous agents,” which was authored by Hans Selye of McGill University, Montreal, Canada [1]. The essence of this report was that rats exposed to a variety of nocuous or toxic agents (e.g. cold, surgery, forced […]

Andor Szentivanyi and the Beta Adrenergic Theory of Allergy and Asthma

Andor Szentivanyi and the Beta Adrenergic Theory of Allergy and Asthma

Historical Perspectives Fifty six years ago Andor Szentivanyi and colleagues were the first to document with exact scientific methodology in animal experiments that the nervous system regulates anaphylactic reactions and antibody production. At that time Szentivanyi was a resident at the Medical School of Debrecen in Hungary. He observed that adrenaline did not inhibit the […]