An Association between Widespread Pain and Serum IL-8 Levels in Fibromyalgia Patients

An Association between Widespread Pain and Serum IL-8 Levels in Fibromyalgia Patients

Ozdolap S, et al. recently reported, at the European League against Rheumatism Annual European Congress of Rheumatology, June 10-13, 2015, a positive correlation between widespread pain and serum IL-8 in patients with fibromyalgia (FM).

This substantiates previous work indicating that the pro-inflammatory chemokine IL-8 may contribute to the pathogenesis of fibromyalgia (Wang H. et al., 2009). Of note, higher cerebrospinal fluid (CSF) levels of IL-8 in FM patients were also recently reported (Kadetoff D. et al., 2012; Kosek E. et al., 2015). Interestingly, exercise interventions might exert an anti-inflammatory effect, as exercise appear to reduce serum IL-8 and IL-6 levels.

IL-8, also known as neutrophil chemotactic factor is a chemokine known to activate neutrophils and is an important factor for the migration and infiltration of neutrophils at inflammation sites.

Other pro-inflammatory cytokines, such as interleukin (IL)-17A might also be involved in the development of FM.

The role of IL-8, in general, as a mediator of pain was first suggested by F.Q. Cunha et al. back in 1991.

Read More: healio.com/rheumatology

Source: Cover Image: Collage: (Left): Solution structure of IL-8 as published in the Protein Data Bank (PDB: 1IL8); author: Ramin Herati; Credit: Wikimedia Commons: https://commons.wikimedia.org/wiki/File:IL8_Solution_Structure.rsh.png (Right) photobucket.hu/Iam1ShadyLady via Food and Fibromyalgia Pain on www.examiner.com http://www.examiner.com/article/food-and-fibromyalgia-pain

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