Stress and Catecholamines Up-Regulate Proinflammatory Cytokine Production and Neutrophil Infiltration in Experimental Colitis

Stress and Catecholamines Up-Regulate Proinflammatory Cytokine Production and Neutrophil Infiltration in Experimental Colitis

A recent Brain, Behavior and Immunity study indicates that psychological stress contributes to the exacerbation of the murine model of colitis by promoting the mobilization and entry of neutrophils in the colon. This appears to be achieved by the up-regulation of pro-inflammatory cytokine and chemokine production and STAT3 signaling, and involves β1/β2-adrenergic receptors activation. Inflammatory […]

Hans Selye and the 80th Birthday of Stress Research

Hans Selye and the 80th Birthday of Stress Research

Stress research has been around for 80 years but has perhaps never been more actual and trendy as in recent years. The term ‘stress’ (psychological) is extremely popular and the general public, as well as celebrities, frequently use and occasionally abuse this term to describe situations causing agitation or alteration of their wellbeing. In PubMed, […]

Chronic Stress Induces Shrinkage of Medial Amygdala Neurons in Mice: Recovery by the Fast-Acting Candidate Antidepressant Acetyl-L-Carnitine

Chronic Stress Induces Shrinkage of Medial Amygdala Neurons in Mice: Recovery by the Fast-Acting Candidate Antidepressant Acetyl-L-Carnitine

A recent study in Molecular Psychiatry provides new evidence that chronic stress generates structural remodelling of the brain amygdala, and particularly the shrinkage of medial amygdala neurons in mice. Chronic stress has been linked to cognitive impairment, but it is also known that stress modifies the neuronal architecture in several brain cognitive areas. However, little […]

The Innate Immune System Senses Psychological Stress through the ATP/P2X7R-Inflammasome (NLRP3) Cascade

The Innate Immune System Senses Psychological Stress through the ATP/P2X7R-Inflammasome (NLRP3) Cascade

COMMENTARY ARTICLE on the study by Masaaki Iwata et al., Biological Psychiatry, 2015, doi: 10.1016/j.biopsych.2015.11.026. Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor Mental disorders are a very common condition. However, the pathophysiology of many of these disorders still remains elusive and more importantly, a […]

Deficiency of Stress Resilience in Late Adolescence Linked To Increased Risk of Hypertension in Adulthood

Deficiency of Stress Resilience in Late Adolescence Linked To Increased Risk of Hypertension in Adulthood

A new study published in the journal Heart indicates that men with low stress resilience during youth are prone to approximately 40% increase in the risk of developing hypertension in later life. Of note, the combination of low stress resilience and high body mass index (BMI) triples the hypertension risk. High blood pressure is a […]

Stress May Start Driving Cardiovascular and Metabolic Risk Early In Life: Evidence from the 1958 British Birth Cohort Study

Stress May Start Driving Cardiovascular and Metabolic Risk Early In Life: Evidence from the 1958 British Birth Cohort Study

Ashley Winning et al. from the Harvard T.H. Chan School of Public Health, Boston, Massachusetts report in the the Journal of the the American College of Cardiology that psychological stress in childhood, adulthood or persistent across a person’s life can contribute to high cardiovascular and metabolic risk. Many clinical and epidemiological studies have documented the […]

New Evidence that Stress May Increase the Risk of Developing Dementia and Alzheimer’s: the Einstein Aging Study

New Evidence that Stress May Increase the Risk of Developing Dementia and Alzheimer’s: the Einstein Aging Study

According to a recent report published in the journal Alzheimer Disease & Associated Disorders stress may increase up to 30% the risk of developing amnestic mild cognitive impairment (aMCI) or dementia. Mild cognitive impairment is a significant risk factor for the development of dementia and Alzheimer’s disease. Moreover, among all MCI subtypes, patients with amnestic […]

Stress, Stress Hormones and the Immune System

Stress, Stress Hormones and the Immune System

Stress, Stress Hormones and the Immune System provides an extensive overview on the interactions between the neuroendocrine and immune systems and the effects of stress hormones on immunity. This volume is perhaps the first book focusing on the cross-talk between the brain, the stress and immune systems, addressing some fundamental and clinical implications. The 1st […]

Psychoneuroimmunology: Stress, Mental Disorders and Health (Progress in Psychiatry)

Psychoneuroimmunology: Stress, Mental Disorders and Health (Progress in Psychiatry)

Another excellent book devoted to the interdisciplinary area of research known as psychoneuroimmunology (PNI). The field bridges together psychiatry, neurology, neuroendocrinology and immunology. The book is the result of a collaborative work of many international experts including Cobi J. Heijnen, Pranela Rameshwar, Nancy G. Klimas and many others. Psychoneuroimmunology: Stress, Mental Disorders and Health deals […]

The Psychoneuroimmunology of Chronic Disease: Exploring the Links between Inflammation, Stress, and Illness

The Psychoneuroimmunology of Chronic Disease: Exploring the Links between Inflammation, Stress, and Illness

The Psychoneuroimmunology of Chronic Disease delves into the complex interactions between the brain and immune system, and between inflammation, stress and human diseases. Importantly, it also offers both fundamental and clinical perspectives on how these interactions may influence common complex inflammatory maladies such as heart disease, diabetes, multiple sclerosis, Alzheimer s, and autoimmune disorders. The […]

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