Neuroendocrine-Immunology Progress and Development Stories: 2016 in Review

Neuroendocrine-Immunology Progress and Development Stories: 2016 in Review

Editorial Neuroendocrine-immunology has achieved substantial progress and growth over the last year. As the BrainImmune mission is to promote the advancement of this research field, it is becoming a tradition to recapitulate the latest developments in this relatively new interdisciplinary area that bridges neurosciences and immunology. Note that this is not a complete list, but […]

Beta-Adrenoceptors and Tumor Development: Novel Concepts and Clinical Implications

Beta-Adrenoceptors and Tumor Development: Novel Concepts and Clinical Implications

Evolving Concepts Over the last 3 decades, an increasing body of evidence suggests that catecholamine-dependent signalling may represent a major link between chronic stress and tumor progression. Studies addressing the relationship between stress-activated pathways and cancer progression suggest that stress-induced production of adrenaline and noradrenaline, besides affecting the anti-tumor immune response also displays direct tumor-promoting […]

Hans Selye and the 80th Birthday of Stress Research

Hans Selye and the 80th Birthday of Stress Research

Stress research has been around for 80 years but has perhaps never been more actual and trendy as in recent years. The term ‘stress’ (psychological) is extremely popular and the general public, as well as celebrities, frequently use and occasionally abuse this term to describe situations causing agitation or alteration of their wellbeing. In PubMed, […]

More Evidence that Norepinephrine and β3-Adrenoreceptors May Drive Melanoma Progression & Aggressiveness

More Evidence that Norepinephrine and β3-Adrenoreceptors May Drive Melanoma Progression & Aggressiveness

A report recently published in Oncotarget shows that the β3-adrenoreceptors are involved in melanoma aggressiveness, and that these receptors, expressed on several accessory cells, may orchestrate their function and thus, sustain melanoma progression. Recent research indicates that stress and stress mediators contribute to cancer development and/or progression. It appears that in this process a major […]

The Power of Positive Stress and a Research Roadmap

The Power of Positive Stress and a Research Roadmap

Evolving Concepts Stress is everywhere. In evolutionary terms, given the range of stressful environmental challenges faced, the human race could not have evolved without developing successful physiological strategies to cope with and overcome potentially life-threatening challenges on a daily basis. The need for a robust response to an acute stress is well-established. Not only do […]

Cool Housing Temperature and Cold Stress Linked To Immunosuppression and Increased Tumor Growth in Experimental Animals

Cool Housing Temperature and Cold Stress Linked To Immunosuppression and Increased Tumor Growth in Experimental Animals

In the December 2013 issue of the Proceedings of the National Academy of Sciences of the USA Kathleen Kokolus et al., from the Roswell Park Cancer Institute, Buffalo, NY and the US Environmental Protection Agency, NC, demonstrate that a cool ambient housing temperature may affect the outcome of a broad range of experimental endpoints, including […]

New Animal Stress Model Links the Stress-Induced T-helper 2 Shift to Colon Cancer Growth

New Animal Stress Model Links the Stress-Induced T-helper 2 Shift to Colon Cancer Growth

In the October 2013 issue of Biochemical and Biophysical Research Communications, Ni Hou and colleagues from the Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi, China, demonstrated that a novel form of sound stress induced a T helper (Th)2 shift and that this is related to colon cancer progression in mice. Numerous epidemiological reports indicate […]

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

Overview article The catecholamines dopamine, noradrenaline and adrenaline are well established neurotransmitters and neurohormones. Sympathoadrenergic pathways are pivotal to the communication between the nervous system and the immune system, and the role of dopaminergic pathways in the modulation of immune response is being increasingly unveiled. However, over the last two decades, evidence has accumulated regarding […]

Beta Blockers Improve Survival in Ovarian Cancer Patients

Beta Blockers Improve Survival in Ovarian Cancer Patients

At a recent meeting of the American Society of Gynecologic Oncology in Los Angeles, CA., Anil Sood, MD, and colleagues from the MD Anderson Cancer Center in Houston, reported that patients with advanced ovarian cancer had significantly better survival if they took beta blockers. In the past few years, more than a dozen studies have […]

Aging Alters Sympathetic Noradrenergic Innervation and Immune Reactivity in the Lymphoid Organs: Strategies to Reverse Neuro-Immune Senescence

Aging Alters Sympathetic Noradrenergic Innervation and Immune Reactivity in the Lymphoid Organs: Strategies to Reverse Neuro-Immune Senescence

Overview article Current therapeutic strategies in medicine emphasize the influence of “mind” over “body” in the maintenance of health and development, progression, and recovery from diseases. This is achieved by interactions between the nervous system, endocrine system, and immune system in controlling health and disease mediated through various psychological, emotional, and spiritual factors. Several studies […]

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